Dr. Joachim Schnier

Profile

Academic positionEmeritus
Research fieldsGeneral Genetics, Functional Genome Research
KeywordsCancer, Glioblastoma, ribosomes, Glycogen Metabolism, Cell cycle

Current contact address

CountryUnited States of America
CityDavis
InstitutionUniversity of California, Davis

Host during sponsorship

Prof. Dr. Terrance LeightonDepartment of Microbiology and Immunology, University of California, Berkeley, Berkeley
Start of initial sponsorship01/08/1987

Programme(s)

1986Feodor Lynen Research Fellowship Programme

Publications (partial selection)

2012DP Richman, K Nishi, SW Morell, JM Chang, MJ Ferns, RL Wollmann, RA Maselli, J Schnier, MA Agius : Acute severe animal model of anti-muscle-specific kinase myasthenia: combined postsynaptic and presynaptic changes. . In: Arch Neurol., 2012, 453-460
2012DP Richman, K Nishi, MJ Ferns, J Schnier, P Pytel, RA Maselli, MA Agius: Animal models of antimuscle-specific kinase myasthenia. . In: Ann N Y Acad Sci. , 2012, 140-147
2009K Nishi, H Inoue, JB Schnier, RH Rice: Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes. . In: J Cell Biochem., 2009, 63-72
2008JB Schnier, K Nishi, WR Harley, FA Gorin: An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas. . In: J Neurooncol. , 2008, 19-26
2008Joachim Schnier: Flash XML Applications. Elsevier, Focal Press, 2008
2007R Maselli, H Dris, J Schnier, J Cockrell, R Wollmann: Congenital myasthenic syndrome caused by two non-N88K rapsyn mutations. . In: Clin Genet. , 2007, 63-65
2005JB Schnier, K Nishi, PH Gumerlock, FA Gorin, EM Bradbury : Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer. . In: BMC Urol. , 2005, 6
2004F Gorin, W Harley, J Schnier, B Lyeth, T Jue: Perinecrotic glioma proliferation and metabolic profile within an intracerebral tumor xenograft. . In: Acta Neuropathol. , 2004, 235-244
2003JB Schnier, K Nishi, A Monks, FA Gorin, EM Bradbury: Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.. In: Biochem Biophys Res Commun., 2003, 126-134
2002K Nishi, JB Schnier, ME Bradbury: Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1. . In: Exp Cell Res., 2002, 233-243
2001A Kaiser, K Nishi, FA Gorin, DA Walsh, EM Bradbury, JB Schnier : The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase. . In: Arch Biochem Biophys., 2001, 179-187
2000NG Oikonomakos, JB Schnier, SE Zographos, VT Skamnaki, KE Tsitsanou, LN Johnson: Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site. . In: J Biol Chem. , 2000, 34566-34573
1999JB Schnier, G Kaur, A Kaiser, SF Stinson, EA Sausville, J Gardner, K Nishi, EM Bradbury, AM Senderowicz: Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein. . In: FEBS Lett., 1999, 100-104
1999PC Mack, DR Gandara, C Bowen, MJ Edelman, T Paglieroni, JB Schnier, EP Gelmann, PH Gumerlock: RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma. . In: Clin Cancer Res., 1999, 2596-2604
1998K Nishi, JB Schnier, EM Bradbury: The accumulation of cyclin-dependent kinase inhibitor p27kip1 is a primary response to staurosporine and independent of G1 cell cycle arrest. . In: Exp Cell Res., 1998, 222-231
1998SE Rought, PM Yau, JB Schnier, LF Chuang, RY Chuang: The effect of heptachlor, a chlorinated hydrocarbon insecticide, on p53 tumor suppressor in human lymphocytes.. In: Toxicol Lett., 1998, 29-36
1996JB Schnier, K Nishi, DW Goodrich, EM Bradbury : G1 arrest and down-regulation of cyclin E/cyclin-dependent kinase 2 by the protein kinase inhibitor staurosporine are dependent on the retinoblastoma protein in the bladder carcinoma cell line 5637.. In: Proc Natl Acad Sci U S A. , 1996, 5941-5946
1994JB. Schnier, DM. Gadbois, K. Nishi, EM. Bradbury : The kinase inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells. . In: Cancer Res., 1994, 5959-5963
1992SY. Choi, BJ. Scherer, J. Schnier, MV. Davies, RJ. Kaufman, JW. Hershey: Stimulation of protein synthesis in COS cells transfected with variants of the alpha-subunit of initiation factor eIF-2. . In: J Biol Chem. , 1992, 286-293
1991J. Schnier, HG. Schwelberger, Z. Smit-McBride, HA. Kang, JW. Hershey: Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae.. In: Mol Cell Biol., 1991, 3105-3114
1990YJ. Bignon, JY. Shew, D. Rappolee, SL. Naylor, EY. Lee, J. Schnier, WH. Lee : A single Cys706 to Phe substitution in the retinoblastoma protein causes the loss of binding to SV40 T antigen.. In: Cell Growth Differ. , 1990, 647-651
1990J. Schnier, HS. Gewitz, SE. Behrens, A. Lee, C. Ginther, T. Leighton: Isolation and characterization of Bacillus stearothermophilus 30S and 50S ribosomal protein mutations.. In: J Bacteriol. , 1990, 7306-7309
1990J. Skouv, J. Schnier, MD. Rasmussen, AR. Subramanian, S. Pedersen: Ribosomal protein S1 of Escherichia coli is the effector for the regulation of its own synthesis. . In: J Biol Chem., 1990, 17044-17049
1990JW. Hershey, Z. Smit-McBride, J. Schnier: The role of mammalian initiation factor eIF-4D and its hypusine modification in translation. . In: Biochim Biophys Acta. , 1990, 160-162
1989P. Linder, PF. Lasko, M. Ashburner, P. Leroy, PJ. Nielsen, K. Nishi, J. Schnier, PP. Slonimski.: Birth of the D-E-A-D box. . In: Nature, 1989, 121-122
1989Z. Smit-McBride, J. Schnier, RJ. Kaufman, JW. Hershey: Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein. . In: J Biol Chem. , 1989, 18527-18530
1988K. Nishi, F. Morel-Deville, JW. Hershey, T. Leighton, J. Schnier: An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly. . In: Nature, 1988, 496-498
1988J. Schnier, S. Thamm, R. Lurz, A. Hussain, G. Faist, B. Dobrinski.: Cloning and characterization of a gene from Rhizobium melilotii 2011 coding for ribosomal protein S1. . In: Nucleic Acids Res., 1988, 3075-3089
1988J. Schnier, K. Nishi Temperature-sensitive mutants with alterations in ribosomal protein L24 and isolation of intra- and extragenic suppressor mutants. . In: H.P. Noller, K. Moldave, Methods Enzymol. . 1988. 706-709
1988K. Nishi, J. Schnier: The phenotypic suppression of a mutation in the gene rplX for ribosomal protein L24 by mutations affecting the lon gene product for protease LA in Escherichia coli K12. . In: Mol Gen Genet., 1988, 177-181
1987K. Nishi K, M. Müller, J. Schnier: Spontaneous missense mutations in the rplX gene for ribosomal protein L24 from Escherichia coli. . In: J Bacteriol., 1987, 4854-4856
1987J. Schnier: The synthesis of heat-shock proteins after a decrease in translational capacity in Escherichia coli. . In: J Gen Microbiol., 1987, 3151-3158
1986K. Nishi, J. Schnier: A temperature-sensitive mutant in the gene rplX for ribosomal protein L24 and its suppression by spontaneous mutations in a 23S rRNA gene of Escherichia coli. . In: EMBO J., 1986, 1373-1376
1986J. Schnier, G. Stöffler, K. Nishi: Deletion and insertion mutants in the structural gene for ribosomal protein S1 from Escherichia coli. . In: J Biol Chem. , 1986, 11866-11871
1986J. Schnier, M. Kitakawa, K. Isono: The nucleotide sequence of an Escherichia coli chromosomal region containing the genes for ribosomal proteins S6, S18, L9 and an open reading frame.. In: Mol Gen Genet., 1986, 126-132
1985J. Schnier, G. Faist Comparative studies on the structural gene for the ribosomal protein S1 in ten bacterial species. . In: Mol Gen Genet., 1985, 476-481
1985K. Nishi, ER. Dabbs, J. Schnier: DNA sequence and complementation analysis of a mutation in the rplX gene from Escherichia coli leading to loss of ribosomal protein L24. . In: J Bacteriol., 1985, 890-894
1985J. Schnier, S. Isono, AG Cumberlidge, K. Isono: Unstable mutations caused by regional tandem multiplications in the gene for ribosomal protein S4 show thermosensitivity in Escherichia coli.. In: Mol Gen Genet. , 1985, 265-270
1984J. Schnier, K. Isono: Insertion of IS1 into the rpsE gene for ribosomal protein S5 causes cold-sensitivity in Escherichia coli. . In: Mol Gen Genet. , 1984, 364-366
1982J. Schnier, M. Kimura, K. Foulaki, AR Subramanian, K Isono, B. Wittmann-Liebold : Primary structure of Escherichia coli ribosomal protein S1 and of its gene rpsA.. In: Proc Natl Acad Sci U S A., 1982, 1008-1011
1982J. Schnier, K. Isono 1982 Mar 25;10(6):1857-65.: The DNA sequence of the gene rpsA of Escherichia coli coding for ribosomal protein S1.. In: Nucleic Acids Res. , 1982, 1857-1865
1980K. Isono, J. Schnier, M. Kitakawa : Genetic fine structure of the pyrE region containing the genes for ribosomal proteins L28 and L33 in Escherichia coli.. In: Mol Gen Genet., 1980, 311-317
1979J. Schnier, K. Isono: The gene for ribosomal protein L25 (rplY) maps at 47.3 min near nalA in Escherichia coli K-12.. In: Mol Gen Genet., 1979, 313-318
1977P. Fortnagel, J. Schnier: Ribosomal dimers produced by dimers of aurintricarboxylic acid.. In: FEBS Lett. , 1977, 288-292